bupropion-induce d climbing throu gh d -1 and d-2 dopamine receptor activation

BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATION

Intraperitoneal (IP) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-ad...

Dopamine D-1 and D-2 receptor antagonists potentiate analgesic and motor effects of morphine.

To examine the role of dopamine receptor subtypes mediating analgesic and motor responses to opioids, rats were pretreated with either saline or a selective D-1 or D-2 dopamine receptor antagonist 10 min prior to morphine (12 mg/kg IP). Analgesic response latency was determined using the hot plate test (52.5 degrees C and 55 degrees C), and catalepsy was assessed using the abnormal posture test...

D 1 and D 2 Dopamine Receptors Form Heterooligomers and Co - internalize Following Selective Activation of Either Receptor φ

D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates.

In primates, CB(1) cannabinoid receptor agonists produce sedation and psychomotor slowing, in contrast to behavioral stimulation produced by high doses of dopamine receptor agonists. To investigate whether dopamine agonists attenuate the sedative effects of a cannabinoid agonist in monkeys, we compared the effects of D(1) or D(2) dopamine receptor agonists on spontaneous behavior in three to si...

Effects of dopamine D 1 and D 2 receptor antagonists on laryngeal 1 neurophysiology in the rat 2

Effects of dopamine D1 and D2 receptor antagonists on laryngeal 1 neurophysiology in the rat 2 Xin Feng, Victor M. Henriquez, Judith R. Walters, Christy L. Ludlow 3 1 Laryngeal and Speech Section, Medical Neurology Branch, National Institute of 4 Neurological Disorders and Stroke, Building 10, Room 5D38, 10 Center Drive MSC 5 1416, Bethesda, MD 20892-1416, USA 6 2 Neurophysiological Pharmacolog...

Effects of dopamine D 1 and D 2 receptor antagonists on laryngeal 1 neurophysiology in the rat

Effects of dopamine D1 and D2 receptor antagonists on laryngeal 1 neurophysiology in the rat 2 Xin Feng, Victor M. Henriquez, Judith R. Walters, Christy L. Ludlow 3 1 Laryngeal and Speech Section, Medical Neurology Branch, National Institute of 4 Neurological Disorders and Stroke, Building 10, Room 5D38, 10 Center Drive MSC 5 1416, Bethesda, MD 20892-1416, USA 6 2 Neurophysiological Pharmacolog...